Briarcliff, a former tuberculosis hospital, is now an insane asylum run by the Catholic church. It's 1964 and and the asylum houses some seriously disturbed individuals. The day to day administrator is in the hands of Sister Jude who works under the general supervision of Monsignor Timothy Howard. Her chief nemesis however is their in-house medical officer, Dr. Arthur Arden who is frequently seeing patients in the night - patients who die and are disposed of immediately. Briarcliff's latest patient is Kit Walker, aka Bloody Face, accused of murdering several young women but unable to stand trial. Sister Jude is tough as journalist Lana Winters learns when she starts poking around the place.